Single-use molded silicone manifolds are custom made to meet your batch filling and sampling needs in drug and vaccine production.

Molded manifolds, manufactured from platinum-cured Class VI silicone, eliminate the need for barbed fittings while providing a seamless transition from tubing to connection for a continuous, unrestricted, leak-proof flow. Designs range from simple molded sanitary ends to complex configurations with varying lengths of tubing and several molded connections.

Single Use Molded Manifolds are not intended for implantation or continuous steam applications.

Key Features

• Eliminates entrapment issues and leaks associated with barbed fittings
• Custom manufactured with Y’s, T’s, crosses, reducers, mini and
  standard Tri-Clamps®, stoppers and other container closures, and tubing
• Components are permanently molded into one, single-use manifold
• Provides a smooth inner surface without seams or crevices for even, uninterrupted flow
• One animal-derived-ingredient-free material contact surface throughout the assembly
• Reduces end-user component inventory and assembly labor time and expense
• Single use reduces the risk of cross contamination
• Also reduces downtime by eliminating certain cleaning validation requirements
• Provides flexibility in facility design—changes are less costly than with hard piping
• Sterilizable by autoclave and gamma radiation
• Retains silicone’s wide range of temperature resistance: -100°F to 400°F
• Imparts no taste or odor to critical streams
• Manufactured and packaged in a Class 7 (Class 10,000) ISO-certified clean room
• Documented lot traceable with identification on bags
• Documented quality control
• Experienced engineers available for technical assistance
• Complete validation package available upon request
• DocuLink™ (patent pending) manifold assembly identification permanently molds a part number and/or lot number onto a manifold for quick visual reference and to track the part back to its origins (see back page)
• Optional RFID tags easily attach to assemblies for identification purposes providing reliable electronic data storage and current status of assemblies from inception to disposal

This example of an assembly made from tubing and barbed fittings is comprised of nine separate pieces of tubing of varying sizes and lengths, plus four fittings that require insertion into the tubing at three points each, with double ties wraps installed at each connection for secure attachment. An AdvantaPure Single-Use Process System is a complete unit, packaged in a sealed polybag and ready for use. Leaks, entrapment, and contamination concerns involved with barbed fitting connections are eliminated. Labor, numerous inventories, and time to assemble the manifold is unnecessary. 37 Components 1 Component

Molded Connections Molded Ends Silicone Tubing Select from a number of different crevice-free connections—Y’s, T’s, crosses, and reducers. MORE ABOUT SILICONE MANIFOLD CONNECTIONS Molded mini and standard silicone Tri-Clamp® fittings with protective backing cups may be incorporated into process systems. Platinum cured silicone tubing is available from stock in nearly 50 sizes. It, too, is platinum cured and meets Class VI standards. Complete biocompatibility validation packages are available.

The cutaway view above of a molded Y connector shows the smooth interior created by the molding process.

This cutaway of a plastic barbed Y fitting shows the potential areas of flow disruption and entrapment created by the barbs.